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discuss the biological functions of exosomal non-coding RNAs in OA, highlighting their role in modulating gene expression at post-transcriptional and post-translational levels [48]

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At the level of the pituitary, in vitro studies of pituitary cells and in vivo findings in mice harvesting a somatotroph-specific knockout of the insulin receptor have demonstrated that insulin directly suppressed pituitary GH secretion independent of the IGF-I receptor (IGF-IR) (29, 30)

Anti-obesity effects of -amylase inhibitor enriched-extract from white common beans (Phaseolus vulgaris L.) associated with the modulation of gut microbiota composition in high-fat diet-induced obese rats