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Proper dosage titration involves starting at 200-250mcg daily for 2-4 weeks to establish baseline tolerance, then increasing by 50-100mcg increments every 2-4 weeks based on subjective response and side effect profile until reaching optimal therapeutic dose or maximum tolerated dose

and in vivo, long-acting GHRH treatment also induced pituitary DNA damage in mice

Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age

But that has not been established in humans, and there are very limited ongoing clinical trials to illuminate the real efficacy and safety of these peptides