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These challenges led to widespread shortages across nearly the entire class of GLP-1 medications

Critical evaluation Strengths - Addresses unmet need for disease modifying diabetes therapies, also applicable to related metabolic diseases - Combines regenerative potential with metabolic control - Supported by robust preclinical models and biomarker endpoints Limitations - Translational challenges in moving from preclinical models to human cells regeneration - Long term safety must be carefully evaluated, given its role in gastric physiology - Regulatory guidelines for such therapies are still evolving

l e Roux Researchers obtained data from 262 adults who began using liraglutide or semaglutide from January 2023 to March 2024 and had at least two follow-up visits after GLP-1 initiation (mean age, 46 years

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