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Nicotine, IL-6 and Other Pro-Inflammatory Factors One of the main causes of death from COVID-19 is acute respiratory distress syndrome (ARDS), and the main mechanism of ARDS is the cytokine storm, which is caused by immune effector cells releasing large amounts of pro-inflammatory cytokines (e.g., TNF-, IFN-, IL-1, IL-6, IL-12.) and chemokines (e.g., CCL2, CCL3, CCL5) (Xu et al., 2020)
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