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Answer: After age 30, adults may lose between 3% to 8% muscle mass each decade, and the rate of muscle loss may accelerate after age 60 (Volpi, Curr Opin Clin Nutr Metab Care 2018)

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Because of this origin, it is studied as a potential communicator between mitochondria and the rest of the cell, a role researchers refer to as retrograde mitochondrial signaling