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Tirzepatide as a Type 2 Diabetes Treatment As mentioned, animal research has shown that tirzepatide regulates hypothalamic feeding centers via GIP signaling, resulting in improved glucose handling and reduced food intake [11]

Tirzepatide lacks glucagon receptor activation, so split dosing preserves more of its efficacy

Finding maintenance dose Most people : 5-10mg weekly maintains weight Some need : 2.5mg weekly for maintenance Few require : 12.5-15mg to prevent regain Process : Reduce dose gradually, monitor weight for 4 weeks at each level