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En 1999, un estudio encontr que el 17,8% de los varones y el 22,4% de las mujeres de Arabia Saud sufren de niveles bajos de actividad de la glutatin reductasa como consecuencia de la deficiencia de riboflavina

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While therapeutic dosing generally produces concentrations below 0.5 mol/L, values in people taking recommended dosages have been reported to be very close to the lower limit of APAP-CYS concentration associated with acetaminophen toxic overdoses (1.0 mol/L)

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