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Understanding Tirzepatide Mechanism of action Tirzepatide, as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, exerts its effects by interacting with both these incretin hormone receptors, exhibiting a broad range of physiological actions beneficial for glucose homeostasis and weight loss

It regulates appetite, improves blood sugar control, and supports metabolic function regardless of whether you take it in the morning or at night

However, if you go back to how you were eating once off semaglutide, and do not adopt the necessary lifestyle changes to maintain the weight loss, it is likely that you will gain the weight back