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However, when viral infection, environmental stress, or immunosuppression impairs these defenses, microbes from the oral cavity and URT can aberrantly colonize the LRT, markedly increasing the risk of BRD through pathogenic mechanisms and microbial agents similar to those described in the URT section above

Alternate nostrils: If instructed or desired, repeat the nasal spray administration process in the alternate nostril using the same technique

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