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Similar content being viewed by others Key facts Brain cancer cells (including cancer stem cells (CSCs)) from glioblastoma (GBM) and medulloblastoma (MB), rely on high iron uptake and storage to support proliferation, survival, and stemness and thus exhibit an iron addiction

The multiyear project was initiated by Xingya Jiang PhD19, who is now a postdoctoral research fellow at Harvard Medical School/Brigham and Womens Hospital, and was continued by Qinhan Zhou, a PhD candidate in chemistry at UT Dallas

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Altogether, these elastase-mediated processes lead to the development of an emphysema-like phenotype