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Pre-treatment evaluation should consider: Comprehensive medical history, specifically asking about prior pancreatitis episodes Assessment of alcohol consumption patterns Lipid panel to identify hypertriglyceridemia (triglycerides 500 mg/dL warrant management to reduce risk) Evaluation for gallbladder disease, particularly in patients with obesity The FDA continues post-marketing surveillance through the FAERS database, and healthcare providers are encouraged to report any suspected pancreatitis cases to the FDA MedWatch program

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