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A recent systematic review of case reports of adverse events linked to GLP-1R agonists highlighted cases of pancreatitis associated with liraglutide and exenatide, although none with semaglutide (47)

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Glutathione S-transferase omega 1 inhibition activates JNK-mediated apoptotic response in breast cancer stem cells

Human studies have not shown the same effect, but the family-history exclusion for medullary thyroid cancer is kept in place as a precaution