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Spectrochim Acta A Mol Biomol Spectrosc

Genistein, a polyphenolic nonsteroidal compound derived from plants, is among the most extensively studied phytoestrogens, exhibiting estrogen-like bioactivity without significant toxic effects during prolonged use (183)

Currently, there are several strategies for overcoming chemoresistance in cancer, including discontinuous dosing, modifying drug concentrations, combination therapy, and the use of natural products ( In this review, we aim to understand the mechanisms of chemotherapy resistance in GC and to explore the potential of TCM and its active components as chemotherapy sensitizers in reversing chemotherapy resistance and improving curative effect in GC

doi: 10.1104/pp.119.3.1047 228 Vargas-HernandezM.Macias-BobadillaI.Guevara-GonzalezR