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Because GH and IGF-1 signaling can influence fluid balance, connective tissue, metabolism, and glucose regulation, potential GH-axis-related effects include: Water retention Peripheral edema Joint stiffness or discomfort Muscle aches Paresthesias or tingling Carpal-tunnel-like symptoms Changes in insulin sensitivity or glucose handling Adult GH replacement literature consistently identifies fluid-retention-related effects including edema, arthralgia, carpal tunnel syndrome, and paresthesias as common side effects of GH treatment
This medication represents a promising advancement in the treatment of obesity and overweight conditions, providing a tool for those struggling with weight management
Participants underwent pre-study baseline testing which included serum analysis of muscle damage and oxidative stress markers, maximal isometric strength, maximal muscle power and body composition analysis
Also, female rat kidney revealed acute tubular necrosis at highest dose used in this study (Fig
