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This leads to increased expression of the HIF-1 subunit HIF-13 and up-regulation of VEGF mRNA expression

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This study shows that alterations in the Wnt pathway may contribute to these symptoms because this pathway regulates the homeostasis in self-renewing tissues and has additionally organ-specific effects

4-Phosphopantetheinylation Specific multi-enzyme complexes, which need to carry out several reactions in an orderly manner, may require the covalent attachment of a 4-phosphopantetheine arm to a carrier domain (or protein)