semaglutide and cardiovascular outcomes in diabetes Oral High-Risk Type 2 Diabetes: @NEJM 🥸 Among persons with type 2 DM and ASCVD, CKD, or both, the use of oral semaglutide was associated with a semaglutide cardiovascular outcomes study news

11 12 GLP-1s lower blood sugar, blood pressure, body weight, and inflammationall of which reduce strain on the heart and blood vessels 13 GLP-1 receptors are found in the heart and arteries, where they may also improve endothelial function, increase nitric oxide, and reduce oxidative stress, helping stabilize plaque and improve how the heart uses energy, especially during stress

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GLP-1 agonists reduced lung fibrosis in mice after COVID-19 infection

But let's be honest, "ideal conditions" are often a moving target in a busy lab environment