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To this end, it is important noting that the major risk factors for severe COVID-19 illness are aging, comorbidities, smoking habit, all characterized by intrinsically low antioxidant capacity and high ROS/GSH ratios (Polonikov, 2020) (see Figure 1 )

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The purpose of the modeling was to answer questions posed by experiments or experimentalists and to investigate mechanisms of regulation in one-carbon metabolism

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