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Review of Ginkgo biloba -induced toxicity, from experimental studies to human case reports

This approach addresses multiple pathophysiological defects simultaneously, creating more robust and sustained metabolic improvements than single-pathway interventions can achieve

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The presence of three chiral centers in the saturated side chain, presenting as either R- or S-configuration, leads to eight different stereoisomers, among which only -tocopherol in its RRR conformation is selectively retained and incorporated into lipoproteins, while non--tocopherol congeners are preferentially metabolized and excreted (Podszun and Frank 2021)