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Shrestha S, Maharjan S

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The National Cancer Institute warns that "too many enemas of any kind can cause changes in normal blood chemistry, chemicals that occur naturally in the body and keep the muscles, heart, and other organs working properly." Some experts specifically warn against using coffee as the stimulant in an enema, citing a lack of research on its potential effects

Most side effects of semaglutide use kick in within the first few days and typically include: Nausea (affects about 70% of users) Vomiting (around 20-30% experience this) Diarrhea (roughly 30% of people) Stomach pain (common in the first weeks) Fatigue (your bodys working overtime) The good news