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The VKORC1 gene is located on chromosome 16p11.2 and is composed of 4 exons that generate three alternatively spliced mRNAs, each of which encode a distinct protein isoform

Additionally, we observed an induction of iron regulatory protein 2 (IRP2), a major component of the iron response pathway which is activated upon iron-sulfur cluster synthesis dysfunction 30 (Fig

S1P is a signaling sphingolipid produced by the phosphorylation of sphingosine by two sphingosine kinases, SphK1 and SphK2 (Maceyka et al., 2012)

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