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21 Patients on low dose naltrexone/bupropion (8mg naltrexone/180mg bupropion twice daily) reported 5% weight loss while patients on high dose treatment (16mg naltrexone 180mg bupropion twice daily) reported 6.1% weight loss over 56 weeks

In addition, the triple-agonist profile makes Retatrutide particularly relevant for researchers investigating energy expenditure and metabolic pathway signalling

Frances Chung reports research support from the Ontario Ministry of Health and Long-Term Care Innovation Grant, ResMed Foundation, University Health Network Foundation (Toronto, ON, Canada)

32 The primary outcome for the trial was the first occurrence of a major adverse cardiovascular event (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke)