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Afamelanotide (MT-1) was approved by the EMA in 2014 and FDA in 2019 under the brand name Scenesse for erythropoietic protoporphyria

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Antioxid Redox Signal 4(3):405414 Urata Y, Yamamoto H, Goto S, Tsushima H, Akazawa S, Yamashita S, Nagataki S, Kondo T (1996) Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells