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Epigenetic regulation of cell life and death decisions and deregulation in cancer

In the 24-week, placebo-controlled factorial study of initial therapy with JANUVIA in combination with metformin, the incidence of hypoglycemia was 0.6% in patients given placebo, 0.6% in patients given JANUVIA alone, 0.8% in patients given metformin alone, and 1.6% in patients given JANUVIA in combination with metformin

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These adverse effects are generally mild to moderate and improve over time, but they are the most frequent reason for treatment discontinuation