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At present, a large-scale phase III RCT of 2-year exenatide treatment in patients with PD, defined as a Hoen and Yahr (H&Y) stage of 2.5, is ongoing

PMID: 39265666

Physiological Actions The physiologic effects of neurosteroids are mediated through direct interactions with neurotransmitter receptors and transporters, and indirectly via promotion of second-messenger signaling cascades (99103)

Funding Work in the authors groups has been supported by the National Institute for Translational Neuroscience (Brazil), the Brazilian agencies Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) and Fundao de Amparo Pesquisa do Estado do Rio de Janeiro (FAPERJ) (to STF and FDF), and Alzheimer Society Canada and Weston Brain Institute (to FDF)