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To view or add a comment, sign in Cumulative Effects of Vicadrostat and Empagliflozin on Albuminuria in CKD AJKD ebruary 09, 2026 Aldosterone excess may lead to accelerated chronic kidney disease (CKD) progression, elevated blood pressure (BP), and an increased risk of cardiovascular events.1,2 The mechanisms of kidney and cardiovascular injury by aldosterone include fibrosis, inflammation, and dysfunctional remodeling

On the contrary, excessive ROS levels cause cell injury by damaging proteins, lipids, and nucleic acids, leading to different conditions, such as neurological diseases, hypertension, diabetes, atherosclerosis, heart failure, chronic kidney disease, and cancerogenesis [2]