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Cardiovascular Diseases Hyperhomocysteinemia : Elevated homocysteine levels are commonly linked to MTHFR mutations, particularly the C677T variant, which increases the risk of: Coronary artery disease Heart attack Stroke Venous thromboembolism (VTE) Peripheral artery disease 2

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Changes in metabolic syndrome The proportions of subjects in the weight management trial with metabolic syndrome at baseline, week 28 and week 52 are shown by treatment group in Figure 6