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Excessive activation of NMDA-Rs and the associated Ca 2+ influx result in stimulation of calpain I and nNOS [73]

Sustainable optimization includes: Nutrition and diet quality Sleep both duration and quality Stress management Physical activity and strength training Hormone balance (assessed properly with lab work) Replacing deficient nutrients before adding new compounds Working with a qualified physician who can monitor for changes Peptides may have a role but they belong inside a comprehensive plan supervised by someone who can monitor your bloodwork, your symptoms, and your overall response over time

in other words, it is only efficacious if it is also bioavailable [47]

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