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Pfizer reported that its dose-optimization studies of once-daily formulations of danuglipron met key pharmacokinetic objectives and confirmed a formulation and dose with the potential to deliver a competitive efficacy and tolerability profile in Phase III testing, based on earlier studies of twice-daily danuglipron
Genet Med (2019) doi: 10.1038/s41436-019-0442-0 90 WolfendenCWittkowskiAHareDJ
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Supplements, NSAIDs, and Pancreatitis Risk Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen are safe to use occasionally with semaglutide, but chronic NSAID use increases the risk of gastrointestinal bleeding, especially when combined with GLP-1's effects on stomach function
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