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El Asmar R, Panigrahi P, Bamford P et al (2002) Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure

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Why this trial matters : First ADC to move into the 1L HER2+ metastatic setting Breaks a decade-long treatment paradigm in first-line breast cancer care Confirms ADCs as frontline platforms, not just late-line salvage therapies Roche Giredestrant Delivers the First Phase III Win for an Oral SERD in Early Breast Cancer Roches oral SERD giredestrant reduced the risk of invasive disease recurrence versus standard endocrine therapy in the Phase III lidERA trial in ER-positive, HER2-negative early breast cancer, marking the first major advance in adjuvant endocrine therapy in decades

What the evidence supports today is biological plausibility worth a proper trial