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Common schedule: Starting dose: 0.25 mg weekly Increase every 4 weeks Maintenance: up to 2.4 mg (Wegovy) How to take: Same day each week With or without food Injection sites: abdomen, thigh, upper arm Side Effects of Semaglutide Common: Nausea Vomiting Constipation Diarrhea Decreased appetite Monitoring: Patients are monitored for: tolerance weight loss progress overall health Semaglutide vs Tirzepatide Semaglutide targets GLP-1 receptors, while tirzepatide targets both GLP-1 and GIP

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Endnotes and References The efficacy estimand with weight management represents efficacy in all randomized participants who remained on the study intervention (with possible dose modifications) without initiating prohibited weight management treatments