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For researchers tracking this space, the key trials to watch in 2026 include the remaining TRIUMPH program readouts for retatrutide, the GLORY-OSA trial for mazdutide in obstructive sleep apnea, and the first Phase 1 data from several quadruple-agonist programs entering clinical development

Clinical effectiveness The SCALE trials demonstrated average weight loss of 57% over 56 weeks, which is modest compared with Mounjaro and Wegovy

Although mild heart rate increases are common, certain symptoms warrant prompt medical attention

For some healthy adults, frequent use may be fine, but daily sauna is not automatically better