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5.2 Seizures During clinical trials and the postmarketing experience, there have been reports of seizures in patients treated with CHANTIX

Also, even though several prescription-only, as well as over-the-counter, nicotine replacement products were available to smokers during this time period, not enough smokers used nicotine replacement therapy (NRT) when trying to quit and, consequently, the availability of NRT has not had a significant effect on population-level prevalence of smoking over the years 50

Part of its rationale was that meta-analyses are observational in nature and can at times be confounding

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