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N.WatzH.TrinkmannF.WeckmannM.et al (2023)
TGF-1 and IGF-1 influence the re-differentiation capacity of human chondrocytes in 3D pellet cultures in relation to different oxygen concentrations
While we could demonstrate evidence of L-carnitine deficiency and accumulation of -BB as direct consequences of gbh-1/BBOX1 deficiency, the absence of significant changes in other metabolites confirms that the loss of GBH-1 selectively impacts the L-carnitine biosynthesis pathway without significantly affecting other metabolic pathways in amino acid, nucleotide, and energy metabolism that are not dependent on L-carnitine (Fig
As described above, ROUT outlier analysis was applied to all data using a cut-off of Q = 0.1
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